Genesis 22:2

Thy only begotten, or thy most beloved, as if he had been an only child; in which sense the word is often taken, 1 Paralipomenon xxix. 1. Ismael was still living; but Isaac was the only son of Sara, the most dignified wife. --- Lovest. Hebrew, "hast loved" hitherto; now thou must consider him as dead. He has been to thee a source of joy, but now he will be one of tears and mourning. --- Of vision. Septuagint, "high," being situated on Mount Moria, by which name it was afterwards distinguished, ver. 14. (Menochius) --- Every word in this astonishing command, tended to cut Abraham to the heart; and thence we may the more admire his strength and disinterestedness of his faith. He could hope, in a manner, against hope, knowing in whom he had trusted, and convinced that God would not deceive him, though he was at a loss to explain in what manner Isaac should have children after he was sacrificed. (Haydock)