1 Samuel 5:12

And the men that died not were smitten with the emerods, being extremely ill with the boil-sickness; and the cry of the city went up to heaven, for the Philistines were forced to acknowledge that in this place the almighty hand of the God of Israel was revealed. Thus the Lord revenged the sacrilege of the heathen in laying their hands upon the ark consecrated to Him. When unbelievers presume to attack the Word of God, to blaspheme and persecute the Word of Salvation, and, in addition, refuse to bow under the chastening hand of God, He often visits them with very severe plagues and terrors.