Matthew 10:22

“And you will be hated of all men for my name's sake. But he who endures to the end, the same will be saved.”

Note how in the chiasmus this parallels their being sheep among wolves. The hatred of ‘all men' (whether Jew, Samaritan or Gentile) because they went out in the Name of the Messiah was something to be expected (Isaiah 66:5) from wolves. But whatever they faced they must recognise that they must endure. For final salvation waited ahead for all who would finally endure (and thus Judas was excluded). That would be the test of their genuineness, that they were ‘confirmed', made strong, to the end (1 Corinthians 1:8), kept by the power of God through faith unto salvation (1 Peter 1:5). There must be no turning back (compare Luke 9:62) or quailing before them. His disciples must be firm and courageous, and endure to the end (compare Joshua 1:9).

‘To the end.' This almost certainly indicates until death or rapture, rather than just the end of the persecution, although it includes the latter. Those who are His are revealed by this fact, that God never lets them go (John 10:29). They are His sheep (Matthew 10:16). They are thus known by Jesus, they hear His voice, they follow Him, and thus they will never perish and none will pluck them from His hand (John 10:27).

‘Will be saved.' That is they will be presented holy, unblameable and unreproveable before Him (Colossians 1:22), testified to by Jesus (Matthew 10:32), and will enter with triumph into His presence, along with Abraham, Isaac and Jacob (Matthew 8:11). They will be taken to ever be with the Lord (John 14:1; 1 Thessalonians 4:17).