Mark 15:36

full of vinegar Burning thirst is the most painful aggravation of death by crucifixion, and it was as He uttered the words, "I thirst," that the soldier ran and filled a sponge with vinegar, or the sour wine-and-water called posca, the ordinary drink of the Roman soldiers.

and put it on a reed i. e. on the short stem of a hyssop-plant (John 19:29).

Let alone According to St Mark, the man himself cries "Let be;" according to St Matthew, the others cry out thus to him as he offers the drink; according to St John, several filled the sponge with the sour wine. Combining the statements, together we have a natural and accurate picture of the excitement caused by the loud cry.