While they were serving the Lord and fasting. Fasting and prayer often go together, and these men must have been asking God to show them how they could do more to spread the Good News of Christ. The Holy Spirit said to them. He spoke through one of the prophets. Compare Acts 20:23; Acts 21; Acts 10-11. Set apart for me. Both Barnabas and Paul had been chosen by God to preach to the Gentiles. This, then, is a request to officially identify them.

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Old Testament