Genesis 25:22
22 And the children struggled together within her; and she said, If it be so, why am I thus? And she went to enquire of the LORD.
Gen. 25:22. "And the children struggled together in the womb." I believe this had reference to the spiritual war that is in the soul of the believer, Christ's spouse, between the flesh and spirit: the flesh lusteth against the spirit, and the spirit against the flesh, and these two are contrary one to another.
Gen. 26:5