For he shall give his angels charge over thee - literally, “He will give ‘command’ to his angels.” That is, he would instruct them, or appoint them for this purpose. This passage Psalms 91:11 was applied to the Saviour by the tempter. Matthew 4:6. See the notes at that passage. This, however, does not prove that it had an original reference to the Messiah, for even if we should suppose that Satan was a correct and reliable expounder of the Scriptures, all that the passage would prove as used by him would be, that the righteous, or those who were the friends of God, might rely confidently on his protection, and that Jesus, if he was of God, might do this as others might. On the sentiment in the passage, to wit, that God employs his angels to protect his people, see the notes at Psalms 34:7; compare the notes at Hebrews 1:14.

To keep thee in all thy ways - To preserve thee wheresoever thou goest.

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