For what if some were without faith? shall their want of faith make of none effect the faithfulness of God?

'Some' -i.e. some of the Jewish people. The fact was that many Jews had not proved faithful, many rejected the very Messiah foretold in the utterances they possessed.

'make of none effect the faithfulness of God?' -'nullify' (NASV)

The utterances of God which had been entrusted to the Jewish people contained many promises to bless them. But when Paul wrote, many Jews still stood in an unblessed condition. Was this God's fault? Certainly not! The very word 'some' infers that other Jews are 'faithful' and are receiving God's promised blessing. God has kept 'faith', it is man who hasn't.

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Old Testament