They that are in the flesh; in a fleshly state; the same as "they that are after the flesh," as verse Romans 8:4.

Cannot please God; because a fleshly state is contrary to that spiritual state which God requires. For this reason they should no longer continue their wicked and dangerous course, but should turn from it and live. As those who seek their chief good in earthly things cannot please God, and so long as they continue this course show that they are at enmity with him, they ought without delay to renounce it, become his cordial friends, and show this by believing on his Son, and obeying his commands.

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Old Testament