Genesis 25:21

And Isaac entreated the Lord for his wife,.... Was very earnest and constant in his supplications for her, as the word signifies, as is observed by Jarchi; or, "before his wife" a, she being present, and joining with him in his prayers: the reason was,

because she [was] barren; which appeared by the length of time they had been married, which was near twenty years, see Genesis 25:26. The Jewish writers b say, that, after twenty years, Isaac took her and went with her to Mount Moriah, to the place where he was bound, and prayed that she might conceive; putting the Lord in mind of the promise he there made of the multiplication of Abraham's seed, Genesis 22:17:

and the Lord was entreated of him; he granted him his request; for, though God has purposed and promised to do many things for his people, yet he will be sought unto by them to do them for them:

and Rebekah his wife conceived; two sons at once, as it follows.

a לנכח אשתו "praesente uxore sua", Munster, Fagins. b Pirke Eliezer, c. 32. Targum. Jon. in loc. Shalshalet Hakabala, fol. 3. 1.