Seleucia (se-lrû'shĭ-ah; Lat. sĕl'eu-sî'a). Acts 13:4, Acts 14:26. The seaport of Antioch, and the place at which Paul and Barnabas embarked, and to which they returned on their first missionary journey. It was on the Mediterranean, about five miles north of the river Orontes, and was founded by Seleucus Nicator, died b.c. 280.