2 Kings 19:22

and lift[R.V. lifted] up thine eyes on high The name by which Jehovah is often called is -the Most High" (cf. Psalms 56:2). To utter reproaches and blasphemies against Him betrays a great uplifting of the eyes, a terrible excess of arrogancy.

the Holy One of Israel This title of God, which occurs very frequently in Isaiah, signifies not only that God Himself is holy and specially gracious unto Israel, but that He makes the people holy also, separate from the rest of the world and sanctified by and for Himself. It expresses both the praise of God, and the privilege of His people.