Galatians 4:16

ὥστε is often used in the sense of therefore to introduce an imperative or an affirmative conclusion in the Epistles of Paul, but not an interrogation. I can see no reason here for making the clause interrogative: the rendering I am therefore become an enemy to you is quite in harmony with the context, which assumes the existence of some actual estrangement. This estrangement is attributed to plain speaking which had given offence to the disciples. As he had seen no trace of coldness at the time of his recent visit, he must be referring to some language which he had used on that occasion. Circumstances forced him to take up strong ground at that time on the subject of circumcision and to denounce the opposition and intrigues which he had encountered from the Pharisaic party.