Now. beseech you, brethren, by our Lord Jesus Christ, and by the love of the Spirit, that ye strive together with me in your prayers to God for me;

'by our Lord Jesus Christ, and by the love of the Spirit' -'if you have any regard to Christ, or if the Holy Spirit has wrought in your heart any love to Christ or his people,. beseech you to pray for me.' (Plummer)

'strive together with me' -implies strenuous effort. Here earnest prayer. (Vincent p. 176) (Colossians 4:12; Acts 12:5)

'But the man doesn't believe he is the only one with something to offer (Romans 15:29). He doesn't believe he is the only on with. "hotline" to the Godhead.' (McGuiggian p. 436)

Think about it: An apostle is asking for the prayers of "ordinary" members! 'Paul takes it for granted that prayers make. difference..and Paul refuses to hide his needs. When he needs help he asks for it..What. freedom this man must have enjoyed. True he endured much pressure and loneliness and tears; but for all that he must have been one of the freest men who ever lived. He was utterly enslaved to Jesus Christ and altogether free. He was unashamed to ask for help.' (McGuiggan p. 437)

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Old Testament