neither, because they are Abraham's seed, are they all children: but, In Isaac shall thy seed be called.

Here is Paul's first proof that inheriting the promises of God, were never based on 'sole physical descent'. For even the Jewish people accepted this fact. Abraham had other children (Ishmael-one physically descended from Abraham), who weren't regarded as true children of Abraham (i.e. those that would inherit God's promises to Abraham).

'thy seed be called' -means 'shall be acknowledged' by God really to be seed for thee (Lenski p. 592).

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Old Testament