Conflict or struggle, in allusion to what he has just said of his striving, chap Colossians 1:29. In the original Greek the two words agree, like "struggling" and "struggle." It is an inward conflict, the object of which he explains in the following verse.

As many as have not seen my face in the flesh; the obvious meaning of these words is, that the Colossians were among those who had never enjoyed Paul's personal ministry.

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Old Testament