Revelation 14:10

Those that do yield a subjection to him, and profess his faith, shall drink of the wine of the wrath of God; that is, shall feel the severity of God's judicial dispensations, which in Scripture are expressed by the wine cup of his fury, Jeremiah 25:15; see also Job 21:20 Psalms 75:8 Isaiah 51:17; either from the intoxicating quality of wine, or the stupifying quality of it, when mixed with myrrh, or other stupifying things. But here it is said without mixture, which signifies their sensible feeling of the effects of Divine wrath. And he shall be tormented with fire and brimstone in the presence of the holy angels, and in the presence of the Lamb; that is, in short, he shall go to hell at last; the exquisiteness of which torments, as to the pain of sense, is set out by fire and brimstone; brimstone being a material in which fire holds longest to torment any flesh put into it.